Testosterone is the main sex hormone in people assigned male at birth. It’s responsible for the development of typically male characteristics and maintaining them through life.
Methyltestosterone is a manufactured version of testosterone. It’s been around for decades, but it’s not used as much in medicine these days.
So what’s the difference between methyltestosterone vs testosterone? This article will give you an overview of how these drugs compare, including how they’re used, their pros and cons, potential side effects, and how they’re administered.
Chemical Structure and Mechanism of Action
Both testosterone and methyltestosterone are steroid hormones, but they differ in their chemical structures, which impacts how they’re processed by the body.
Testosterone
Testosterone’s chemical formula is C19H28O2. It works by binding to androgen receptors inside cells of target tissues. Some testosterone is converted to dihydrotestosterone (DHT) or estradiol to have its effects.
Methyltestosterone
Methyltestosterone, with the chemical formula C20H30O2, is essentially testosterone with an added methyl group (CH3) at the 17th carbon position. That small addition makes a big difference!
That methyl group slows down the breakdown of the drug, allowing it to be taken orally. Testosterone is broken down by the liver too quickly to be effective in pill form. Methyltestosterone is more resistant to this “first-pass metabolism” in the liver, making it orally bioavailable.
Medical Uses and Indications
Both testosterone and methyltestosterone have legitimate medical applications, though their usage has evolved over time.
Testosterone
Testosterone is primarily used in Testosterone Replacement Therapy (TRT) for men diagnosed with hypogonadism. This condition occurs when the body doesn’t produce enough testosterone naturally. There are two main types of hypogonadism:
- Primary hypogonadism: This is due to a problem with the testicles themselves.
- Secondary hypogonadism: This stems from issues with the pituitary gland or hypothalamus, which control testosterone production.
Testosterone is also used to treat delayed puberty in adolescent males and to manage certain types of breast cancer in women.
Methyltestosterone
Methyltestosterone was once a common treatment for male hypogonadism, prized for being an oral androgen (taken by mouth). It also saw use in treating breast cancer in women, similar to testosterone, and sometimes for delayed puberty in males.
However, methyltestosterone has largely fallen out of favor. This is primarily due to its potential for liver toxicity compared to newer testosterone formulations, which offer safer and more effective delivery methods.
Administration and Dosage
Testosterone and methyltestosterone aren’t administered in the same way, and they don’t have the same typical dosages. Here’s what to know:
Testosterone
Testosterone can be administered in a variety of ways, including, potentially, an Androderm patch alternative:
- injections (either into a muscle or under the skin)
- transdermal patches
- gels
- topical solutions
- buccal tablets (placed between your gum and cheek)
- implants
Because there are so many different delivery methods, the dosage of testosterone depends on the formulation and the individual’s needs.
Methyltestosterone
Methyltestosterone usually comes in tablet form, to be taken by mouth.
The dosage is typically lower than it would be for injectable testosterone, because it’s absorbed effectively in the digestive system.
However, it’s important to keep in mind that because of its shorter half-life, methyltestosterone may need to be taken more frequently.
Benefits and Efficacy
Both testosterone and methyltestosterone can provide similar benefits, but they also differ in important ways.
Testosterone
Testosterone can help with many things, including potentially addressing issues related to obesity and testosterone:
- Building muscle mass and strength
- Increasing bone density
- Boosting sex drive and sexual function
- Improving mood and energy levels
Methyltestosterone
Methyltestosterone may have similar effects as testosterone, such as building muscle mass, increasing strength, and improving libido and energy levels.
However, it’s essential to realize that while methyltestosterone can be effective, its benefits are often outweighed by its adverse effects and the availability of safer alternatives.
For example, methyltestosterone has a high risk of liver damage compared to other forms of testosterone. Because of this, it’s not often prescribed by doctors.
Side Effects and Risks
Both methyltestosterone and testosterone come with a range of potential side effects and risks. Here’s a breakdown:
Testosterone
- Common side effects: Expect things like acne, oily skin, potential hair loss, and even gynecomastia, which is breast enlargement in men.
- Cardiovascular risks: Testosterone can increase your red blood cell count, which could raise the risk of blood clots.
- Prostate issues: There’s a risk of prostate enlargement and potentially stimulating prostate cancer.
- Mood changes: Some people experience irritability and aggression.
Methyltestosterone
Methyltestosterone shares many of the same side effects as testosterone, including acne, hair loss, gynecomastia, and mood swings. However, it carries some additional, significant risks:
- Liver toxicity (hepatotoxicity): This is a key difference. Methyltestosterone is known to be significantly toxic to the liver. It can cause elevated liver enzymes, cholestasis (a condition where bile flow is blocked), and even liver damage.
- Cardiovascular risks: These risks may be even more pronounced with methyltestosterone compared to testosterone.
- Testosterone suppression: After you stop taking it, your body’s natural testosterone production can be suppressed.
Frequently Asked Questions
Does testosterone make you horny?
Testosterone plays a role in sex drive, and some people may experience an increase in libido when taking testosterone. However, individual responses vary. Other factors, like psychological state and relationship dynamics, also influence sexual desire.
What are the benefits of B12 with methyl?
You may be asking about methylcobalamin, a form of Vitamin B12. Some believe methylcobalamin is easier for the body to absorb and utilize compared to cyanocobalamin, another common form of B12. Potential benefits of methylcobalamin include supporting nerve function, energy production, and red blood cell formation.
Does methyltestosterone increase testosterone?
Yes, methyltestosterone is a synthetic androgen that increases testosterone levels in the body. However, it’s important to remember that it also carries potential risks and side effects, and its use should always be under strict medical supervision.
What is methyltestosterone used for?
Methyltestosterone is primarily used to treat conditions caused by low testosterone levels in males. It may also be prescribed in some cases for certain types of breast cancer in women. Its use is generally declining due to the availability of newer, safer testosterone formulations.
Why was Estratest taken off the market?
Estratest, a combination of esterified estrogens and methyltestosterone, was discontinued by its manufacturer. The decision was likely influenced by factors such as concerns about the risk-benefit profile of combined estrogen and androgen therapy, as well as the availability of alternative treatments for menopausal symptoms.
Summary
Methyltestosterone and testosterone share some similarities, but methyltestosterone is more likely to harm your liver. While methyltestosterone was prescribed more commonly in the past, safer and more effective forms of testosterone are available now.
If you’re considering hormone replacement therapy, it’s important to talk with your healthcare provider to determine the best option for your particular situation. They can help you weigh the risks and benefits of each type of treatment and formulate a plan that works for you.