When men have low testosterone, which may be affected by diet and sugar intake, it can lead to a variety of health concerns. Testosterone replacement therapy (TRT) can bring testosterone levels back to normal.
Kyzatrex and Jatenzo are oral medications used for TRT. Both contain testosterone undecanoate (TU), a synthetic form of testosterone.
Which one is better? This article compares Kyzatrex and Jatenzo, looking at their similarities, differences, and what you and your doctor should consider when choosing between them.
Understanding Kyzatrex and Jatenzo
Both Kyzatrex and Jatenzo are oral testosterone replacement therapies (TRT). Oral testosterone offers a convenient alternative to injections, which are another common method of administering TRT.
The active ingredient in both Kyzatrex and Jatenzo is testosterone undecanoate (TU). Jatenzo was approved by the FDA on March 27, 2019, while Kyzatrex received approval on July 27, 2022. Both medications are available only by prescription.
While they both contain the same active ingredient, the available dosages differ:
- Jatenzo: 158 mg, 198 mg, 237 mg
- Kyzatrex: 100 mg, 150 mg, 200 mg
Comparing effectiveness and side effects
Both Kyzatrex and Jatenzo are prescribed to increase testosterone levels in men with hypogonadism.
Both medications also have a half-life of about 2 hours, meaning that after that time, half of the dose has been eliminated from the bloodstream.
Unfortunately, both medications also have the potential to cause side effects.
Some of the most common side effects are similar for both drugs. For example, your doctor will need to monitor your blood pressure while you’re taking either Kyzatrex or Jatenzo.
However, some reports show that people taking Jatenzo may experience more side effects than those taking Kyzatrex. Some of the most commonly reported side effects of Jatenzo are:
- diarrhea
- heartburn
- worsening mood, or depression
It’s important to keep in mind that every patient responds differently to medication. Talk with your doctor about the possible side effects of each drug and the importance of careful monitoring during treatment.
Safety Information and Risks
Like all prescription drugs, Kyzatrex and Jatenzo come with a list of risks and safety concerns.
Drug Interactions and Contraindications
Both Kyzatrex and Jatenzo have a long list of potential drug interactions. In fact, studies show that 184 drugs are known to interact with both Jatenzo and Kyzatrex.
If you have prostate cancer, cardiovascular issues, or benign prostatic hyperplasia (BPH), your doctor will need to take extra precautions before prescribing either of these medications, especially considering the potential impact of anabolic steroids on PSA levels.
Serious Risks
The most serious risks associated with both medications include worsening BPH, blood clots (venous thromboembolism), sleep apnea, and fertility changes (azoospermia).
Regulatory Information
Both Kyzatrex and Jatenzo are listed as Pregnancy Category X, which means they’re not safe for use during pregnancy and should not be taken by women who are pregnant or may become pregnant.
It’s important to note that both medications have moderate abuse potential and are classified as Schedule III controlled substances.
Cost and Accessibility
Kyzatrex wins, hands down, when it comes to cost. Jatenzo is significantly more expensive, and the price difference is a major factor for many people considering testosterone replacement therapy.
For example, 120 capsules of Jatenzo can run anywhere from $900 to $2,400, while 120 capsules of Kyzatrex cost around $159. Cost is an important consideration, so be sure to discuss it with your doctor.
Frequently Asked Questions
Is enclomiphene worth it?
Whether enclomiphene is “worth it” is a subjective question that depends on your individual circumstances and goals, but medications like Clomiphene Citrate may also be considered. It’s a selective estrogen receptor modulator (SERM) sometimes used off-label to boost testosterone, but it’s essential to discuss the potential benefits and risks with your doctor.
Is oral testosterone better than injections?
Neither oral testosterone nor injections are inherently “better.” Oral testosterone, like Kyzatrex, offers convenience, but injections may have more predictable absorption and avoid liver metabolism issues. The best route depends on your specific needs and preferences, as determined by your doctor.
What strengths does Kyzatrex come in?
Kyzatrex is available in several dosage strengths. Consult the official product information or your doctor for the most up-to-date information on available strengths.
Does Kyzatrex really work?
Kyzatrex has been shown to be effective in some patients for raising testosterone levels. However, individual results can vary. It’s crucial to have realistic expectations and work closely with your doctor to monitor your response to the medication.
What is the number one best testosterone booster?
There is no single “number one best” testosterone booster that works for everyone. The most appropriate treatment depends on the underlying cause of low testosterone and individual factors. Prescription medications like Kyzatrex or Jatenzo are often more effective for significant testosterone deficiency than over-the-counter supplements, but a healthcare provider can guide you to the right option.
In Summary
Kyzatrex and Jatenzo are both oral medications that can help boost testosterone levels if you’ve been diagnosed with hypogonadism.
There are key differences and similarities between them when it comes to how well they work, what side effects they can cause, potential risks, and how much they cost.
If you think you might benefit from testosterone replacement therapy, it’s important to talk with your healthcare provider. They can look at your personal risk factors, medical history, and preferences to decide which TRT option is the best fit for you. Don’t try to make this decision on your own!