Enclomiphene citrate is a selective estrogen receptor modulator, or SERM. That means it affects estrogen receptors in the body.
Doctors prescribe enclomiphene to increase testosterone levels in men who have secondary hypogonadism. It’s also being studied as a possible treatment for male infertility.
If you’re considering taking enclomiphene citrate, it’s important to understand how it works, what it’s used for, and what side effects it can cause.
Understanding Enclomiphene’s Mechanism of Action
How Enclomiphene Works
Enclomiphene works by blocking estrogen receptors in the brain. By doing so, it causes the body to release more luteinizing hormone (LH) and follicle-stimulating hormone (FSH).
These hormones then stimulate the Leydig cells in the testicles to produce testosterone. This process means enclomiphene affects the hypothalamic-pituitary-gonadal (HPG) axis.
Boosting Testosterone Production
When people take enclomiphene, it has a significant impact on their testosterone levels.
Studies have shown that enclomiphene can significantly increase total testosterone (T) levels in men. Some research suggests that enclomiphene’s effectiveness is comparable to topical testosterone treatments.
Therapeutic Uses of Enclomiphene
Researchers have been studying enclomiphene for its potential therapeutic uses, especially in men.
Male Infertility
Enclomiphene citrate may improve semen quality and sperm production, which could help treat male infertility. Some studies suggest it may also improve overall health and well-being.
Secondary Hypogonadism
Enclomiphene has been researched as a way to raise serum total testosterone levels in men with secondary hypogonadism. Importantly, some studies suggest it may do so while maintaining normal sperm counts.
Administration, Dosage, and Onset
Enclomiphene citrate is taken orally, typically available in 12.5mg and 25mg tablets. It’s crucial to discuss the right dosage for you with your doctor. Don’t start taking it without professional guidance.
As for how long it takes to work, don’t expect overnight miracles. You’ll likely need to take it for a few weeks, or even a couple of months, before you start noticing any effects. Patience is key here.
Potential Side Effects and Drug Interactions
Like any medication, enclomiphene citrate can cause side effects and interact with other drugs. It’s important to be aware of these potential issues before starting treatment.
Common Side Effects
Some men report an increased libido, acne, and mood changes, like feeling more irritable.
In general, the side effects are expected to be similar to those experienced with clomiphene.
Drug Interactions
Enclomiphene citrate has moderate interactions with at least 71 drugs and mild interactions with at least 101 drugs. It’s vital to consult with your doctor or pharmacist to review your current medications and supplements before using enclomiphene citrate to avoid any potential negative interactions.
Warnings and Precautions
Enclomiphene citrate is contraindicated in pregnancy and should not be used by women. Caution is also advised for nursing women as it may reduce lactation.
Cost, Accessibility, and FDA Status
If you’re considering enclomiphene citrate, here’s a breakdown of cost, how to get it, and its FDA status:
- Cost: Expect to pay around $50 to $150 per month if you don’t have insurance. Your actual cost will depend on your insurance plan (if any), where you live, and whether you get a generic or brand-name version.
- Accessibility: You’ll need a prescription from a doctor to get enclomiphene citrate.
- FDA Status: The FDA rejected the New Drug Application for enclomiphene in 2015.
Frequently Asked Questions
Will insurance pay for enclomiphene?
Whether your insurance will cover enclomiphene depends on your specific plan and its formulary. Because it’s often prescribed off-label, coverage can be inconsistent. It’s best to check with your insurance provider directly to determine if enclomiphene is covered and what your out-of-pocket costs might be.
What are the negative effects of enclomiphene?
Like any medication, enclomiphene can have potential side effects. Common side effects may include mood swings, hot flashes, temporary blurred vision, and breast tenderness. More serious side effects are rare but possible. It’s important to discuss any concerns or side effects with your healthcare provider.
Can you drink while taking enclomiphene?
While there are no specific contraindications between alcohol and enclomiphene, it’s generally advisable to limit or avoid alcohol consumption. Alcohol can negatively impact hormone levels and potentially interfere with the intended effects of enclomiphene. Discussing this with your doctor is always recommended.
How long does it take for enclomiphene to kick in?
The time it takes for enclomiphene to produce noticeable effects can vary. Some individuals may experience changes in energy levels and libido within a few weeks, while others may require a longer period. Regular blood tests are usually conducted to monitor hormone levels and assess the effectiveness of the treatment over time.
What’s better, Clomid or enclomiphene?
Enclomiphene is a purified form of Clomid. Clomid contains both enclomiphene and zuclomiphene. Zuclomiphene has a longer half-life and may cause more side effects. Because enclomiphene contains only the “good” part of Clomid, it may be a better option, but you should discuss this with your doctor.
Conclusion
Enclomiphene citrate holds promise for some men, but it also comes with limitations. It’s definitely not right for everyone.
Before you consider using it, talk to a healthcare professional. They can help you figure out what’s going on with your body and whether enclomiphene is likely to help.
With proper guidance, using enclomiphene could improve your overall health and well-being. But it’s important to get the right diagnosis and treatment plan from a qualified expert.