Cialis (tadalafil) is a medication that treats erectile dysfunction (ED) and pulmonary arterial hypertension. It’s in a class of medications called phosphodiesterase-5 (PDE5) inhibitors.
Amlodipine is a calcium channel blocker that treats high blood pressure and angina (chest pain). When you take multiple medications, it’s important to understand how they may interact. Some drug combinations can make your medications less effective or raise your risk of side effects.
This article explores the potential interactions between Cialis and amlodipine and how to minimize any risks.
Potential Drug Interactions Between Cialis and Amlodipine
Taking Cialis and amlodipine together can potentially cause problems, so let’s break down the risks and what you should know.
How they interact
Both Cialis and amlodipine can lower your blood pressure, but they do it in different ways. Amlodipine works by relaxing your blood vessels, similar to how an arginine vasodilator functions, making it easier for blood to flow through. Cialis can also lower blood pressure, especially when you take it with other medications that have the same effect.
The real concern is that these two drugs can have an additive effect. If you combine them, it could lead to a significant drop in your blood pressure.
Possible side effects
If your blood pressure drops too low, you might experience dizziness, lightheadedness, or even fainting. These side effects can be risky, especially for older adults who are more prone to falls. Low blood pressure can also affect your cognitive function because your brain isn’t getting enough blood, which may be improved with blood circulation pills and other remedies.
How serious is the interaction?
One report classified the interaction between amlodipine and tadalafil (the active ingredient in Cialis) as “minimally clinically significant.” However, experts still advise caution and say it’s important to seek professional advice.
Even if an interaction is considered “minimally significant,” it doesn’t mean you can ignore it. You need to be aware of the potential risks and monitor yourself for any signs of low blood pressure.
Factors That Can Increase the Risk of Interaction
Certain lifestyle choices and other medications can increase the risks associated with taking Cialis and amlodipine together.
- Alcohol Consumption: Alcohol can lower your blood pressure. Since both Cialis and amlodipine can also lower blood pressure, mixing them with alcohol can amplify this effect. This can lead to dizziness, lightheadedness, and even fainting.
- Grapefruit Juice: Grapefruit juice can affect the levels of amlodipine in your body. It inhibits an enzyme called CYP3A4, which is responsible for breaking down amlodipine. By inhibiting this enzyme, grapefruit juice can increase the concentration of amlodipine in your blood, potentially leading to more side effects.
- Other Medications: Other drugs, such as other blood pressure medications or CYP3A4 inhibitors, can also interact with amlodipine or Cialis. Make sure your doctor knows about every single medication, supplement, and vitamin you take.
Minimizing the Risks of Taking Cialis and Amlodipine Together
If you’re taking both Cialis and amlodipine, here’s how to minimize any potential risks:
- Tell your doctor everything. Make sure your healthcare provider knows about all medications, supplements, and health conditions you have.
- Keep an eye on your blood pressure. Monitor your blood pressure regularly, especially when you start taking either medication or if the dosage changes.
- Easy on the alcohol. Limit alcohol to avoid low blood pressure.
- Take it slow. Get up slowly from sitting or lying down to avoid dizziness.
- Think about alternatives. If you’re worried about interactions, talk to your doctor about other blood pressure meds.
- Follow directions. Stick to the prescribed dosages and don’t take more than you’re supposed to of either drug.
When should you see a doctor?
It’s important to know when to seek medical help if you’re taking Cialis and amlodipine.
Seek immediate medical attention if you experience any of the following:
- Severe dizziness
- Fainting
- Chest pain
Contact your doctor if you notice any unusual or unexpected side effects, such as irritability, which could point to a drug interaction. Also, if your erectile dysfunction or high blood pressure symptoms worsen even while taking medication, let your doctor know.
Finally, schedule regular check-ups with your healthcare provider to keep tabs on your overall health and to make sure your medications are working effectively.
Frequently Asked Questions
Can I take amlodipine and tadalafil (Cialis) together?
Amlodipine and tadalafil can be taken together, but it’s important to be aware of potential interactions. Both medications can lower blood pressure, so taking them together may increase the risk of dizziness, lightheadedness, or fainting, especially when standing up quickly. Talk to your doctor about whether this combination is right for you.
What fruit should I avoid when taking amlodipine?
Grapefruit and grapefruit juice should be avoided while taking amlodipine. Grapefruit can interfere with the way amlodipine is metabolized in your body, potentially leading to increased levels of the drug in your system and a greater risk of side effects.
Who should avoid Cialis?
Cialis should be avoided by individuals who are taking nitrates for chest pain, as this combination can cause a dangerous drop in blood pressure. It’s also not recommended for people with severe heart conditions, uncontrolled high blood pressure, or certain eye problems. Always discuss your medical history with your doctor before taking Cialis.
Can you take Cialis while on blood pressure medication?
Yes, you can often take Cialis while on blood pressure medication, but it requires careful monitoring by your doctor. As mentioned earlier, both Cialis and many blood pressure medications can lower blood pressure, so the combination may need to be carefully managed to avoid adverse effects.
Can I eat bananas when taking amlodipine?
Yes, you can eat bananas when taking amlodipine. There are no known interactions between bananas and amlodipine, so you don’t need to avoid them. Unlike grapefruit, bananas are safe to consume while taking this medication.
Key Takeaways
It’s important to remember that Cialis and amlodipine can interact. Taking them together could increase your risk of low blood pressure and related side effects like dizziness or fainting.
The best way to minimize these risks is to talk openly with your doctor or pharmacist. Tell them about all the medications and supplements you’re taking, and be sure to mention any health conditions you have. This information helps them make the safest recommendations for you.
If you are taking both medications, be sure to monitor your blood pressure regularly. You should also avoid drinking too much alcohol and be careful when standing up or changing positions. Low blood pressure can cause you to fall and seriously injure yourself.
Ultimately, the best course of action is to seek personalized advice from your healthcare provider. They can assess your individual needs and provide tailored guidance on managing your medications safely and effectively.